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Providing written informed consent for PCLS experiments from all patients, lung lobes were obtained immediately after surgical resection at Hannover Medical School or KRH Klinikum Oststadt-Heidehaus. The intention of the study was not to introduce PCLS as a new technique, but to combine established methods and investigate the value of PCLS at a functional level as a long term cultivation model, which in our opinion has been lacking so far. This approach limits pre-clinical CRD research to either animal in-vivo studies or the use of human material from patients with the desired but very advanced disease qualifying them for lung resection. However, most of these studies using PCLS were conducted under short-term culturing conditions (≤72 h) [9, 13, 15], which limits their value to certain questions investigating rapid and acute effects.

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The individual data display lines (51-53) are provided with controllable switches (21-23) and with a control device (31) for controlling said switches (21-23). Aim of the study was to characterize the immune response of human lung tissue to ex vivo HRV infection using Precision-Cut Lung Slices (PCLS). Importantly, vaccination of mice with the non-cytotoxic Ply derivative B (PdB) substantially attenuated Ply-induced progression of lung fibrosis in AdTGFβ1-exposed mice.ConclusionsOur data unravel a novel mechanism by which infection with Spn through Ply release induces progression of established lung fibrosis, which can be attenuated by protein-based vaccination of mice.

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The cytokine levels of TNF-α in PCLS culture supernatants were determined by ELISA. The first control picture of the non-constricted airway was set to 100%. Slices from different donors do not constrict equally at the same day, though the trend towards a steady decrease in reactivity and sensitivity were observed for each donor individually. The capability to fully constrict upon treatment with the highest concentration of Mch, which was observed on the first day, decreased until day 15, with a maximal constriction of 81% (equals 19% initial airway area [IAA] remaining; Table 1).

PCLS have mainly been used to investigate local respiratory irritation and immunotoxicity of potential sensitizers or anti-cancer drugs [9, 29]. This inter-individual variation declined during cultivation, at least for the medium control.

He studied architecture at the Technical University in Stuttgart with Paul Bonatz, amongst others. Like Lilo, he was part of the ‘Bubenbad’ circle of artists. From 1929 he worked as a commercial photographer in Stuttgart where he founded the International School of Higher Photography („Internationale Schule für höhere Fotografie“) in 1950. ‘Raumkunst Becher’ (Room-Art Becher) in Wuppertal, where Lilo’s works were shown in 1965 and 1973. Knaus, like Lilo, was part of the ‘Bubenbad’ circle of artists.

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Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury. Swallowing dysfunction in 101 patients with nephropathic cystinosis: benefit of long-term cysteamine therapy. Diagnostic accuracy of bedside swallow evaluation versus videofluoroscopy to assess dysphagia in individuals with tetraplegia. Effect of weight loss on short-term outcomes and costs of care after head and neck cancer surgery.

direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM) controlling functions with the panel; characterised by control panel details, by setting parameters

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