Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: Past, present, and future


Posted On Aug 18 2019 by

The luminal level of NO was higher in NaHS-treated animals than in control and L-NAME + NaHS groups. NO luminal level in PAG-treated rats was lower than in NaHS-treated group. As shown in Figure 3, this level was significantly increased in NaHS-treated rats compared with the control rats and PAG-treated animals. ). The acid response to distention in PAG + SNP-treated rats was significantly lower than in PAG-treated animals (Figure 1).

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In rat, however, relative potencies of TZU-0460 to cimetidine, given i.v., were 2.8, 2.2 and 1.6 in acid secretion stimulated by histamine, pentagastrin and carbachol, respectively. TZU-0460, given p.o., prevented the formation of gastric ulcers induced by exposure to stress, pylorus-ligation, both pylorus-ligation and acetylsalicyclic acid, indometacin or reserpine in rats. TZU-0460 was about twice as active as cimetidine on these experimental models of gastric ulcers. TZU-0460, given p.o., prevented the formation of duodenal ulcer induced by cysteamine in rats, whereas cimetidine failed to prevent it significantly.

acid secretion in the stomach is controlled by

Chemical stimuli (i.e., partially digested proteins, caffeine) directly activate G cells (enteroendocrine cells) that are located in the pyloric region of the stomach to secrete gastrin; this in turn stimulates the gastric glands to secrete gastric juice. The cephalic phase causes ECL cells to secrete histamine and increase HCl acid in the stomach. There will also be an influence on G cells to increase gastrin circulation.

For the noninvasive measurement of gastric pH, the Heidelberg Detection System (Heidelberg Medical) was applied as described before (29, 30). When the subject arrived in the morning, the pH capsule was prepared by activation for 5 min in a sterile 0.9 NaCl solution and, as indicated by the Heidelberg Detection System software, the capsule was calibrated at pH 1 and pH 7. After calibration, the capsule was swallowed by the subject. When a pH of approximately 1-2 was stable over a period of 3 min, a stable position of the capsule in the stomach was considered to have been achieved. During the measurement, the subjects had to lie down on their left side to make sure that the capsule remained in the stomach.

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Ample data from clinical trials and observational experience have confirmed the utility of these agents in the treatment of acid peptic diseases, with differential efficacy and safety characteristics between and within drug classes. Paradigms in their speed and duration of action have underscored the need for new chemical entities that, from a single dose, would provide reliable duration of acid control, particularly at night.

Gastric mucus secretion was significantly increased and the parietal cell count significantly reduced in L-lysine pre-treated animals. Cannabis sativa has long been known for its psychotropic effect.

Furthermore, they suggest that EOCZ has potential therapeutic application for the treatment of gastric ulcers. [6] [7][8].

AG-1749 inhibited both the (H+ + K+)-adenosine triphosphatase activity in canine gastric microsomes and dibutyryl cyclic AMP-stimulated acid formation in isolated canine parietal cells and suppressed the acid secretion stimulated by histamine, pentagastrin, bethanechol or a peptone meal in Heidenhain pouch dogs; the ID50 values were between 0.2 and 0.7 mg/kg p.o. AG-1749 inhibited both the histamine-stimulated and the basal acid secretion in pylorusligated rats and prevented water immersion stress or aspirin-induced gastric lesions and mepirizole or cysteamine-induced duodenal ulcers in rats; the ID50 values were between 0.3 to 3.6 mg/kg p.o. or i.d.

acid secretion in the stomach is controlled by

Last Updated on: September 25th, 2019 at 1:08 pm, by


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