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In both groups, researchers associated use of the drugs with an increased risk of chronic kidney disease over 10 years. Methods. A total of 293 patients with CRF were compared with 261 hospitalized patients and 181 patients with another chronic disease. Information about AST, endoscopic investigations and indication for therapy were obtained by medical records and patient interviews.
The results of this study have heightened our awareness of poor appetite in our patients, particularly those with lower levels of serum urea, creatinine and albumin. This has enabled us to help through a more targeted and concerted approach by selectively counselling and providing intensive nutritional support for patients in need of such interventions.
The new study findings are based on medical records from over 173,000 VA patients who were prescribed a PPI and over 20,000 other patients prescribed another class of heartburn drug called H2-blockers. Those include brands like Zantac, Pepcid and Tagamet, which are also available over-the-counter. About 20 percent of Americans have been diagnosed with GERD, according to the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.
So, what should you do? Heartburn can be a symptom of many diseases, including gastrointestinal reflux disease (GERD), stomach and duodenal ulcer disease, gall bladder disease, stomach blockage, and diseases of the esophagus. Your doctor is the best person to make the proper diagnosis and recommend the best treatment. If these diseases can be controlled with a short course of PPIs, then long term risk would be reduced.
Over five years, 15 percent of PPI users were diagnosed with chronic kidney disease, versus 11 percent of those on H2-blockers. After the researchers weighed other factors, PPI users still had a 28 percent greater risk. So, he said, people should first make sure they have true gastroesophageal reflux disease (GERD) — where stomach acids chronically rise up into the esophagus because of weakness in a muscle between the esophagus and stomach. It’s possible that the drug users suffer chronic kidney disease more often because they have overall poorer health, he said.
Your physician is the best person to assess your risks and make decisions about long-term treatment. Impact of dialysis on gastroesophageal reflux, dyspepsia, and proton pump inhibitor treatment in patients with chronic renal failure.
However, more than half of the cases of chronic kidney damage and end-stage renal disease associated with PPI use occurred in people without acute kidney problems. To examine potential associations in patients with kidney failure, a team led by Chandan Vangala, MD and Wolfgang Winkelmayer, MD, PhD, ScD (Baylor College of Medicine) analyzed information from the US Renal Data System (USRDS) to identify all hip fracture events recorded between 2009 and 2014 among hemodialysis-dependent patients. All cases were matched with 10 patients on dialysis who did not experience hip fractures.