Determination of acid neutralising power of a commercial antacid tablet: Back Titration

Posted On May 2 2010 by

Experiment 5 – Antacid Analysis

will titrate the remaining HCl with the standardized NaOH to determine the amount of acid that was not consumed by the antacid tablet. Please make sure that you have recorded the molarities of the NaOH and HCl (on the reagent bottles to four decimal places). The alkaline effect of lemon water also neutralizes stomach acid and improves digestion. Mix a tablespoon of lemon juice in hot or warm water and drink a few minutes before eating.

The sample data indicates that Tums neutralizes the largest volume of acid for the lowest price. In fact Tums neutralizes 8.5 mL of acid per penny. Any excess active ingredient in the antacid will continue to neutralize HCl secreted by the stomach until the excess antacid is completely consumed by the reaction.

The combination substantially raises the price, and the addition of the less-effective aluminum hydroxide reduces the antacid benefit. Antacids are the oldest effective medications for heartburn. Chalk (calcium carbonate) has been chewed for centuries to provide some relief and is still popular. Antacid preparations serve to neutralize gastric acid after it is secreted. These still-helpful agents have a continuing role in treating mild, occasional heartburn and supplementing prescription drugs in more severe disease.

This experiment shows how you can measure the amount of hydrochloric acid neutralised by one tablet. This is one measure of the effectiveness of the tablet.

Bend Water with Static Electricity

The principal approach to treatment of GERD is to reduce gastric acidity. There are powerful drugs used to reduce the secretion of acid, which include the histamine2 (H2) receptor antagonists, and the proton pump inhibitors, or PPIs.

In the quest for a better antacid many substances have been tried but no ideal agent has been found. Many virtues have been attributed to these compounds but as far as is known their chief value lies in their acid reducing property. We have, therefore, made analyses of some of the more commonly used substances on a basis in which their neutralizing capacity by titration can be compared with their antacid property within the human stomach. Another disadvantage of calcium carbonate may be the tendency for gastric acid secretion to rebound after calcium is given.

Baking soda can quickly neutralize stomach acid and relieve indigestion, bloating, and gas after eating. For this remedy, add 1/2 teaspoon of baking soda to 4 ounces of warm water and drink. Since too little stomach acid can trigger indigestion, drink apple cider vinegar to increase your body’s production of stomach acid. Add one to two teaspoons of raw, unpasteurized apple cider vinegar to a cup of water and drink for fast relief.

Investigating the effect of acid on indigestion tablets

Occasional indigestion caused by overeating or stress can be safely and temporarily treated with over-the-counter remedies. However, symptoms of indigestion or heartburn (a burning sensation in the chest caused by stomach acid leaking into the esophagus) can indicate more serious problems. Repeated bouts of indigestion, particularly when accompanied by severe pain or vomiting, require medical attention rather than self-medication. In addition, the label on the antacid container should be read in order to identify the active ingredient(s) and to follow the dosage recommendations carefully. Using any antacid in excessive amounts may cause acid rebound, which occurs when the stomach produces more acid than was present initially to overcome the neutralizing effects of antacids.

However, any acid-base reaction producing carbon dioxide is considered a neutralization reaction because the very low pH of the hydrochloric acid is raised to a pH much closer to 7. Standard acid solutions in the range of 0.10 M to 1.0 M HCl work well to simulate the human stomach conditions. Using 0.10 M HCl more closely approximates the conditions in the human stomach but will increase the volume of acid used and will lengthen the amount of time required for the experiment.

For example, if the starting magnesium or aluminum compounds are chlorides, bromides or fluorides, the chloride, bromide or fluoride ions will be substituted with anions such as carbonate, sulfate or phosphate. In the practice of the present invention any water-soluble aluminum compounds may be used, such as an aluminum halide, alkali metal aluminate, aluminum nitrate, aluminum sulfate and the like. Similarly, any water-soluble magnesium compound can be used, such as a magnesium halide, magnesium nitrate, magnesium sulfate and the like. How basic or acidic a solution is depends on the amount of hydrogen ions in it.

Calcium carbonate is fast-acting, non-absorbable, inexpensive, and reacts with acid according to Equation 2. Alginic acid – Prepared from kelp (seaweed), alginate acts as a physical acid barrier for the esophagus in gastroesophageal reflux. It is not an antacid.

Both of these magnesium compounds may produce diarrhea. Therefore, while magnesium-based antacids tend to be laxative, aluminum-based antacids tend to produce constipation. For this reason, some medications, such as Maalox and Mylanta, contain both aluminum and magnesium salts.

The samples are for laboratory use only, have been stored with non-food-grade laboratory chemicals and are not meant for human consumption. Hydrochloric acid solution is toxic by ingestion and inhalation and is corrosive to skin and eyes.

An antacid, while it still has “neutralizing power,” will raise the pH of the stomach to a near-neutral value. Once the “neutralizing power” of the antacid is gone, the pH of the stomach falls below a pH value of approximately 3.0-the point the antacid is used up. For this reason, a pH of 3.0 is a reasonable pH value to use as an endpoint in an antacid titration; thus, methyl orange is an appropriate indicator. Hydrochloric acid is so reactive that it can corrode metals and is therefore strong enough to react with the stomach’s own lining, known as

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